Sure. It is not difficult. For homes, condos, apartments, offices, buildings, etc. simply open the return air vent and stand the panel(s) up in the area inside (behind the filter). For ceiling-type return air vents, you will need to open the vent and place a couple of 1″x3″ boards across the chamber area and lay the panel across them. On rare occasions, the ductwork may be too close and a panel may not fit. Contact us for advice, or to have a custom panel made for your needs.